FEATURES

FAMILY

DESCRIPTION

Also known as CRFR2_HUMAN, CRHR2, CRF2R, CRH2R. G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

Also known as CRFR2_HUMAN, CRHR2, CRF2R, CRH2R. G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding caus ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRHR2

Corticotropin-releasing factor receptor 2

CRHR2

Molecular Synopsis