FEATURES

FAMILY

DESCRIPTION

Also known as S12A1_HUMAN, SLC12A1, NKCC2. Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. When phosphorylated, interacts with PPP3CB.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC12A1

Solute carrier family 12 member 1

SLC12A1

Molecular Synopsis