FEATURES

FAMILY

DESCRIPTION

Also known as GCKR_HUMAN, GCKR. Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961). Interacts (fructose 6-phosphate bound form) with GCK.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GCKR

Glucokinase regulatory protein

GCKR

Molecular Synopsis