FEATURES

FAMILY

inward rectifier-type potassium channel (TC 1.A.2.1) family

DESCRIPTION

Also known as KCJ11_HUMAN, KCNJ11. This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2.

EXTERNAL LINKS

KCNJ11

Mutations

Mutation(s) distribution

Mutations table