FEATURES

FAMILY

DESCRIPTION

Also known as LAGE3_HUMAN, LAGE3, DXS9879E, ESO3, ITBA2. Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LAGE3

EKC/KEOPS complex subunit LAGE3

LAGE3

Molecular Synopsis