FEATURES

FAMILY

DESCRIPTION

Also known as PTPRK_HUMAN, PTPRK, PTPK. Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTPRK

Receptor-type tyrosine-protein phosphatase kappa

PTPRK

Molecular Synopsis