FEATURES

DESCRIPTION

Also known as ZMY11_HUMAN, ZMYND11, BRAM1, BS69. Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth., (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. Homooligomer; forms homooligomers via its C-terminus (PubMed:26845565). Interacts with histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) (PubMed:24675531). Interacts (via MYND-type zinc finger) with NCOR1 (PubMed:10734313). Interacts (via MYND-type zinc finger) with MGA protein (via PXLXP motif) (PubMed:23372760). Interacts (via MYND-type zinc finger) with EZH2 (PubMed:16565076). Interacts with EMSY and E2F6 (PubMed:15947784, PubMed:16565076). Interacts with PIAS1 and UBE2I (PubMed:19766626).

EXTERNAL LINKS

ZMYND11

Zinc finger MYND domain-containing protein 11

ZMYND11

Molecular Synopsis