FEATURES

FAMILY

DESCRIPTION

Also known as DIXC1_HUMAN, DIXDC1, CCD1, KIAA1735. Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DIXDC1

Dixin

DIXDC1

Molecular Synopsis