FEATURES

FAMILY

DESCRIPTION

Also known as UB2V2_HUMAN, UBE2V2, MMS2, UEV2. Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Heterodimer with UBE2N. Binds CHFR.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBE2V2

Ubiquitin-conjugating enzyme E2 variant 2

UBE2V2

Molecular Synopsis