FEATURES

FAMILY

DESCRIPTION

Also known as PTGIS_HUMAN, PTGIS, CYP8, CYP8A1. Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z, 8Z, 11Z, 13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTGIS

Prostacyclin synthase

PTGIS

Molecular Synopsis