FEATURES

FAMILY

DESCRIPTION

Also known as CDKN3_HUMAN, CDKN3, CDI1, CIP2, KAP. May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDKN3

Cyclin-dependent kinase inhibitor 3

CDKN3

Molecular Synopsis