FEATURES

FAMILY

class-I pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as KAT1_HUMAN, KYAT1, CCBL1. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). Homodimer.

EXTERNAL LINKS

KYAT1

Mutations

Mutation(s) distribution

Mutations table