FEATURES

FAMILY

DESCRIPTION

Also known as HCDH_HUMAN, HADH, HAD, HAD1, HADHSC, SCHAD. Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Homodimer (PubMed:10231530, PubMed:10840044, PubMed:16725361). Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1) (By similarity).

Also known as HCDH_HUMAN, HADH, HAD, HAD1, HADHSC, SCHAD. Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hyd ...

EXTERNAL LINKS

HADH

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

HADH

Molecular Synopsis