FEATURES

FAMILY

class-I pyridine nucleotide-disulfide oxidoreductase family

DESCRIPTION

Also known as TRXR1_HUMAN, TXNRD1, GRIM12, KDRF. Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TXNRD1

Mutations

Mutation(s) distribution

Mutations table