FEATURES

FAMILY

DESCRIPTION

Also known as CUL4_CAEEL, cul-4. Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. Part of an E3 ubiquitin-protein ligase complex including cul-4 and ddb-1.

EXTERNAL LINKS

uniprot
enzyme classification

cul-4

Cullin-4

cul-4

Molecular Synopsis