FEATURES

DESCRIPTION

Also known as MONAL_PSEE4, mnl. Pore-forming toxin that contributes to the virulence of P.entomophila against Drosophila, playing an important role in host intestinal damage and lethality. Displays cytolytic and hemolytic activity. Pro-Monalysin forms a stable donut-like 18-mer complex composed of two disk-shaped nonamers held together by N-terminal swapping of the pro-peptides (PubMed:25847242). After proteolytic cleavage, the inactive 18-mer complex probably dissociates into two disk-shaped active nonamers in which the transmembrane segments are unmasked and ready to engage the conformational change leading to the pore formation into the target membrane (PubMed:25847242). Multimerizes into circular-like structures and barrel-like aggregates (PubMed:21980286).

EXTERNAL LINKS

mnl

Mutations

Mutation(s) distribution

Mutations table