FEATURES

DESCRIPTION

Also known as NORG_STAA8, norG. Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Overexpression of norG leads to an increase in the level of resistance to quinolones, associated with a threefold increase in norB transcripts. Disruption of norG leads to an increase in the level of resistance to methicillin, cefotaxime, penicillin G, and nafcillin, associated with a threefold increase in abcA transcripts. Could also have an aminotransferase activity.

EXTERNAL LINKS

uniprot
enzyme classification

norG

HTH-type transcriptional regulator NorG

norG

Structural Ligandability

Domains Chains

Distribution