FEATURES

FAMILY

DESCRIPTION

Also known as R13L4_ARATH, RPP13L4, ZAR1. CC-NB-LRR receptor-like protein required for recognition of pathogenic bacteria type III effectors (T3E) such as Pseudomonas syringae HopZ1a and HopF2a and Xanthomonas campestris pv. campestris (Xcc) XopAC/AvrAC; this recognition requires ZED1-related kinases (e.g. PBL2, ZRK3 and ZED1/ZRK5) (PubMed:20368970, PubMed:26355215, PubMed:28288096, PubMed:30948527, PubMed:30948526, PubMed:28652264). Confers allele-specific recognition and virulence attenuation of HopZ1a (PubMed:20368970). Immunity mediated by RPP13L4/ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1 (PubMed:20368970). Together with ZED1/ZRK5, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens (PubMed:28499073). Interacts with ZED1/ZRK5 (PubMed:24170858). Component of a stable high-order oligomeric complex made of RKS1 and RPP13L4/ZAR1 which recruits ZED1-related kinases (e.g. uridylylated PBL2 and acetylated ZED1/ZRK5) in the presence of ATP and pathogenic bacteria type III secreted effector (T3SE) proteins (e.g. Pseudomonas syringae HopZ1a and HopF2a and Xanthomonas campestris pv. campestris (Xcc) XopAC/AvrAC) to form a wheel-like pentameric resistosome; this complex triggers immunity toward pathogenic bacteria (e.g. X.campestris and P.syringae), especially in vascular tissues (PubMed:26355215, PubMed:30948527, PubMed:30948526). Interacts with RKS1, ZED1/ZRK5, ZRK3, ZRK6 and ZRK15 (PubMed:26355215, PubMed:30948526, PubMed:28652264).

EXTERNAL LINKS

RPP13L4

Disease resistance RPP13-like protein 4

RPP13L4

Molecular Synopsis