FEATURES

FAMILY

DESCRIPTION

Also known as SGMR2_BOVIN, TMEM97, S2R. Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. Interacts with NPC1.

EXTERNAL LINKS

uniprot
enzyme classification

TMEM97

Sigma intracellular receptor 2

TMEM97

Molecular Synopsis