FEATURES

FAMILY

DESCRIPTION

Also known as TCHP_MOUSE, Tchp. Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Interacts with KCTD17 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Tchp

Trichoplein keratin filament-binding protein

Tchp

Structural Ligandability

Domains Chains

Distribution