FEATURES

FAMILY

DESCRIPTION

Also known as YGHU_ECOLI, yghU. Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1-chloro-2, 4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate. Homodimer.

EXTERNAL LINKS

yghU

Mutations

Mutation(s) distribution

Mutations table