FEATURES

FAMILY

DESCRIPTION

Also known as SLLC2_DABSI, LC2. Regulatory subunit of the blood coagulation factor X- and IX-activating enzyme. The enzyme activates coagulation factor X (F10) by cleaving the Arg-Ile bond and is also able to activate coagulation factor IX (F9) and protein S (PROS1) by specific cleavage of Arg-Ile and Arg-Val bonds. May serve as an exosite by which the enzyme recognizes and binds to the Gla domain of factor X (F10) and factor IX (F9) in a calcium-dependent manner. Heterotrimer; disulfide-linked. The heterotrimer consists of 1 heavy chain (a metalloproteinase) and 2 light chains: LC1 and LC2.

EXTERNAL LINKS

uniprot
enzyme classification

LC2

Snaclec coagulation factor X-activating enzyme light chain 2

Mutations

Mutation(s) distribution

Mutations table

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