FEATURES

FAMILY

DESCRIPTION

Also known as PAR10_HUMAN, PARP10. ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). Interacts with MYC (PubMed:15674325). Interacts with PARP14 (PubMed:23473667). Interacts (via-PIP box and ubiquitin-interacting motifs) with PCNA (PubMed:24695737).

EXTERNAL LINKS

PARP10

Mutations

Mutation(s) distribution

Mutations table