FEATURES

FAMILY

DESCRIPTION

Also known as ZTOX_STRPY, ZTOX. Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Phosphorylation is inhibited by cognate epsilon antitoxin. Part of a postsegregational killing (PSK) system involved in the killing of plasmid-free cells. The zeta toxin induces programmed cell death. In the presence of the epsilon antitoxin forms an inactive PezA(2)PezT(2) heterotetramer. The heterotetramer is still able to bind the UNAG substrate.

EXTERNAL LINKS

uniprot
enzyme classification

ZTOX

Toxin zeta

ZTOX

Molecular Synopsis