FEATURES

FAMILY

DESCRIPTION

Also known as FITB_NEIG1, fitB, vapC. Toxic component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. FitAB binds to its own promoter better than FitA alone. The expected nuclease activity was not observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB. Forms a heterodimer with FitA, 4 FitAB heterodimers form a complex that binds to promoter DNA. The complex is also seen in solution. This protein does not actually contact DNA.

EXTERNAL LINKS

uniprot
enzyme classification

fitB

Toxin FitB

fitB

Molecular Synopsis