FEATURES

FAMILY

DESCRIPTION

Also known as ISDC_STAAC, isdC, sirD. Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Monomer. Interacts with IsdA (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

isdC

Iron-regulated surface determinant protein C

isdC

Structural Ligandability

Domains Chains

Distribution