FEATURES

FAMILY

serine-aspartate repeat-containing protein (SDr) family

DESCRIPTION

Also known as SDRD_STAAC, sdrD. Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis. Mediates interactions with components of the extracellular matrix such as host DSG1 to promote bacterial adhesion to host cells. Contributes to the resistance to killing by innate immune components such as neutrophils present in blood and thus attenuates bacterial clearance. Interacts with host DSG1; this interaction increases S. aureus adherence to keratinocytes.

EXTERNAL LINKS

uniprot
enzyme classification

sdrD

Serine-aspartate repeat-containing protein D

sdrD

Molecular Synopsis