FEATURES

DESCRIPTION

Also known as Z36L3_MOUSE, Zfp36l3. Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:15814898, PubMed:26952984). Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG (PubMed:15814898, PubMed:18367448, PubMed:26952984). Involved in placental expression of many genes important for normal placental physiology (PubMed:26952984).

EXTERNAL LINKS

uniprot
enzyme classification

Zfp36l3

mRNA decay activator protein ZFP36L3

Zfp36l3

Structural Ligandability

Domains Chains

Distribution