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FEATURES

DESCRIPTION

Also known as FGL1_RAT, Fgl1. Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. Homodimer. Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2).

Also known as FGL1_RAT, Fgl1. Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds ...

EXTERNAL LINKS

uniprot
enzyme classification

Fgl1

Fibrinogen-like protein 1

Structural Ligandability

Domains Chains

Distribution

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