FEATURES

FAMILY

class IV-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as CI114_HUMAN, SPOUT1, C9orf114. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). Interacts with INCA1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPOUT1

Putative methyltransferase C9orf114

SPOUT1

Molecular Synopsis