FEATURES

FAMILY

DESCRIPTION

Also known as HENMT_HUMAN, HENMT1, C1orf59. Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HENMT1

Small RNA 2'-O-methyltransferase

Structural Ligandability

Domains Chains

0 chains assessed

3 chains not associated with a domain

HENMT1

Structural Ligandability

Domains Chains

Distribution