FEATURES

FAMILY

krueppel C2H2-type zinc-finger protein family

DESCRIPTION

Also known as KLF4_MOUSE, Klf4, Ezf, Gklf, Zie. Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Interacts with MUC1 (via the C-terminal domain) (By similarity). Interacts with POU5F1/OCT4 and SOX2 (PubMed:19816951). Interacts with MEIS2 isoform MeisD and PBX1 isoform PBX1a (By similarity). Interacts with ZNF296 (PubMed:24161396). Interacts with GLIS1 (By similarity). Interacts with BTRC; this interaction leads to KLF4 ubiquitination and subsequent degradation (PubMed:29593216).

Also known as KLF4_MOUSE, Klf4, Ezf, Gklf, Zie. Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15 ...

EXTERNAL LINKS

Klf4

Mutations

Mutation(s) distribution

Mutations table