FEATURES

FAMILY

DESCRIPTION

Also known as TRPC6_MOUSE, Trpc6, Trp6, Trrp6. Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Homodimer; forms channel complex. Interacts with MX1 and RNF24.

EXTERNAL LINKS

uniprot
enzyme classification

Trpc6

Short transient receptor potential channel 6

Mutations

Mutation(s) distribution

Mutations table

Search Mutation