FEATURES

FAMILY

DESCRIPTION

Also known as ACSL3_RAT, Acsl3, Acs3, Facl3. Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804, PubMed:19737935, PubMed:15683247). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis (PubMed:19737935). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (PubMed:9276691, PubMed:8663269). Both isoforms exhibit the same level of activity (PubMed:9276691).

Acsl3

Structural Ligandability

Domains Chains

Distribution