FEATURES

FAMILY

DESCRIPTION

Also known as ILVC2_BACCZ, ilvC2. Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2, 3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2, 3-dihydroxy-isovalerate.

EXTERNAL LINKS

uniprot
enzyme classification

ilvC2

Ketol-acid reductoisomerase (NADP(+)) 2

ilvC2

Molecular Synopsis