FEATURES

FAMILY

DESCRIPTION

Also known as PAM_TAXWC, pam. Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate. Homodimer (PubMed:15878763). Homotetramer, dimer of dimers (PubMed:24786474).

EXTERNAL LINKS

uniprot
enzyme classification

pam

Phenylalanine aminomutase (L-beta-phenylalanine forming)

pam

Molecular Synopsis