FEATURES

FAMILY

DESCRIPTION

Also known as CENPA_KLULA, CSE4. Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Component of the core kinetochore.

EXTERNAL LINKS

uniprot
enzyme classification

CSE4

Histone H3-like centromeric protein CSE4

CSE4

Molecular Synopsis