FEATURES

FAMILY

DESCRIPTION

Also known as RMI1_XENLA, rmi1. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2.

EXTERNAL LINKS

uniprot
enzyme classification

rmi1

RecQ-mediated genome instability protein 1

rmi1

Molecular Synopsis