FEATURES

FAMILY

DESCRIPTION

Also known as ALKB2_HUMAN, ALKBH2, ABH2. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ALKBH2

DNA oxidative demethylase ALKBH2

ALKBH2

Molecular Synopsis