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FEATURES

DESCRIPTION

Also known as MEP50_XENLA, wdr77, mep50. Non-catalytic component of the 20S prmt5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. Required for normal prmt5 methyltransferase activity. Heterotetramer; dimer of heterodimer with prmt5. Interacts with histone h2a and h4 and with nucleoplasmin.

Also known as MEP50_XENLA, wdr77, mep50. Non-catalytic component of the 20S prmt5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosoma ...

EXTERNAL LINKS

uniprot
enzyme classification

wdr77

Methylosome protein 50

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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