FEATURES

FAMILY

DESCRIPTION

Also known as GPAT2_HUMAN, GPAT2. Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. Interacts with PIWIL2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GPAT2

Glycerol-3-phosphate acyltransferase 2, mitochondrial

GPAT2

Molecular Synopsis