FEATURES

FAMILY

carotenoid/retinoid oxidoreductase family

DESCRIPTION

Also known as RETST_HUMAN, RETSAT, PPSIG. Catalyzes the saturation of all-trans-retinol to all-trans-13, 14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RETSAT

All-trans-retinol 13, 14-reductase

RETSAT

Molecular Synopsis