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FEATURES

FAMILY

pectinacetylesterase family

DESCRIPTION

Also known as NOTUM_HUMAN, NOTUM. Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).

Also known as NOTUM_HUMAN, NOTUM. Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoy ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOTUM

Palmitoleoyl-protein carboxylesterase NOTUM

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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