FEATURES

FAMILY

DESCRIPTION

Also known as CNKR3_HUMAN, CNKSR3, MAGI1. Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). Interacts with epithelial sodium channel ENaC. Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails. Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CNKSR3

Connector enhancer of kinase suppressor of ras 3

CNKSR3

Molecular Synopsis