FEATURES

FAMILY

outer membrane OOP (TC 1.B.6) superfamily

DESCRIPTION

Also known as OMP38_ACIB2, omp38, ompA. Functions as a porin (PubMed:9928952). Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor) (PubMed:16008580). Binds peptidoglycan, contributes to cell wall maintenance (Probable). Homotrimer (PubMed:9928952). Forms a pore with a size of 1.3 nm (PubMed:9928952).

EXTERNAL LINKS

uniprot
enzyme classification

omp38

Mutations

Mutation(s) distribution

Mutations table