FEATURES

FAMILY

DESCRIPTION

Also known as PNCB_HUMAN, NAPRT, FHIP, NAPRT1. Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NAPRT

Nicotinate phosphoribosyltransferase

NAPRT

Molecular Synopsis