FEATURES

FAMILY

DESCRIPTION

Also known as RN165_HUMAN, RNF165. E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization (PubMed:26656854).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF165

E3 ubiquitin-protein ligase RNF165

RNF165

Molecular Synopsis