FEATURES

DESCRIPTION

Also known as BUR2_ASHGO, BUR2. Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). Belongs to the BUR kinase complex.

EXTERNAL LINKS

uniprot
enzyme classification

BUR2

Protein BUR2

BUR2

Molecular Synopsis