FEATURES

FAMILY

DESCRIPTION

Also known as CALYP_DROME, calypso. Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Component of the PR-DUB complex, at least composed of calypso and Asx.

EXTERNAL LINKS

uniprot
enzyme classification

calypso

Ubiquitin carboxyl-terminal hydrolase calypso

Mutations

Mutation(s) distribution

Mutations table

Search Mutation