FEATURES

DESCRIPTION

Also known as POGZ_HUMAN, POGZ, KIAA0461, SUHW5, ZNF280E, ZNF635. Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts (via IBM motif) with PSIP1 isoform 1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:19244240, PubMed:25082813, PubMed:29997176).

Also known as POGZ_HUMAN, POGZ, KIAA0461, SUHW5, ZNF280E, ZNF635. Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Pro ...

EXTERNAL LINKS

POGZ

Mutations

Mutation(s) distribution

Mutations table